Biological Sciences

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Andy graduated from the University of Oxford in 1993 with a BA (Hons) degree in Biochemistry. He went on to complete a DPhil in Biochemistry (1997) in the laboratory of Prof. Iain Campbell in Oxford, and continued there as a Research Associate studying the structural biology of the extracellular matrix (ECM) using nuclear magnetic resonance (NMR) spectroscopy as his principal research tool.

Andy joined the School of Biological Sciences at the University of Portsmouth in September 2005 as Senior Lecturer in Biological NMR. He brought with him extensive experience in the study of the structure, function and dynamic properties of proteins by NMR. Since then the focus of his research has turned from the steady-state structure and interactions of the ECM to the mechanisms by which it is degraded by matrix metalloproteinases (MMPs). His research is supported by the Royal Society and the BBSRC.

Teaching Interests and Responsibilities

Level 4: Experimental Biology, Perspectives in Biochemistry

Level 5: Macromolecules (unit coordinator), Biochemistry and Analytical Techniques

Level 6: Biomolecular Science (unit coordinator), Industrial Biotechnology, Molecular Biotechnology

Recent Publications

More recent publications

Publications Before 2008

Millard CJ, Ellis IR, Pickford AR, Schor AM, Schor SL & Campbell ID (2007) The role of the fibronectin IGD motif in stimulating fibroblast migration. J. Biol. Chem. 282, 35530-5.

Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH & Campbell ID (2006) Structural basis of integrin activation by talin. Cell 128, 171-82.

Pagett A, Campbell ID & Pickford AR (2005). Gelatin binding to the ⁶F1¹F2²F2 fragment of fibronectin is independent of module-module interactions. Biochemistry 44, 14682-14687.

Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ & Jackson DG (2004). Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. Mol. Cell 13, 483-496.

Schwarz-Linek U, Pilka ES, Pickford AR, Kim JH, Hook M, Campbell ID & Potts JR (2004). High affinity streptococcal binding to human fibronectin requires specific recognition of sequential F1 modules. J. Biol. Chem. 279, 39017-39025.

Pickford AR & Campbell ID (2004). NMR Studies of Modular Protein Structures and Their Interactions. Chem. Rev. 104, 3557-3565.

Pickford AR and O'Leary JM (2004). Isotopic labeling of recombinant proteins from the methylotrophic yeast Pichia pastoris. Methods in Mol. Biol. 278, 17-33.

Schwarz-Linek U, Werner JM, Pickford AR, Gurusiddappa S, Kim JH, Pilka ES, Briggs JAG, Gough TS, Hook M, Campbell ID & Potts JR (2003). Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper. Nature 423, 177-181.

Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID & Day AJ (2003). The link module from ovulation- and inflammation associated protein TSG-6 changes conformation on hyaluronan binding. J. Biol. Chem. 278, 49261-49270.

Pickford AR, Smith SP, Staunton D, Boyd J & Campbell ID (2001). The hairpin structure of the ⁶F1¹F2²F2 fragment from human fibronectin enhances gelatin binding. EMBO J. 20, 1519-1529.