Pharmacy and Biomedical Sciences
Dr Anthony Lewis
Pharmacy and Biomedical Sciences
Division of Pharmacology
School of Pharmacy and Biomedical Sciences
University of Portsmouth
St Michael's Building
White Swan Road
Portsmouth PO1 2DT
Key Teaching Responsibilities
- Introduction to Anatomy, Physiology and Pharmacology
- Key Skills
- Endocrine and Gastrointestinal Pharmacology
- Respiratory, Renal and Cardiovascular Pharmacology
- Professional Skills in Pharmacology
- MSc Biomedicine – Molecular Medicine
Academic Related Duties
- Unit co-ordinator for Year 1 Review Unit
- Deputy Admissions Tutor
- Personal Tutor
- Faculty Recruitment and Retention Committee Representative for SPBMS
- Genetic Modification (GMAG) Committee Representative for SPBMS
- Facilitator for Inter-Professional Learning (IPLU-1)
- The Physiological Society
- The Biophysical Society
- Higher Education Academy (Bioscience)
- Ion Channel Research Group
- Mammalian potassium channel structure-function relationships in health and disease
- Biophysics and physiology of fungal potassium channels
Techniques used in the lab include electrophysiology (two-electrode voltage clamp and patch clamp), molecular biology, microbiology, biochemistry and immunocytochemistry.
- Dunhill Medical Trust
- Royal Society
Publications before 2008
Cordero-Morales, J.F., V. Jogini, A. Lewis, V. Vasquez, D.M. Cortes, B. Roux & E. Perozo. Molecular driving forces determining potassium channel slow inactivation. Nature Structural and Molecular Biology, 14 (11); 1062-1069, 2007.
Lewis, A., Z.A. McCrossan & G.W. Abbott. MinK, MiRP1 and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. Journal of Biological Chemistry, 279(9); 7884-7892, 2004.
Kemp, P.J., C. Peers, A. Lewis & P. Miller. Regulation of recombinant human brain tandem P domain K+ channels by hypoxia: a role for O2 in the control of neuronal excitability. Journal of Cellular and Molecular Medicine, 8 (1); 38-44, 2004.
McCrossan, Z.A., A. Lewis, G. Panaghie, P.N. Jordan, D.J. Christini, D.J. Lerner & G.W. Abbott. MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. Journal of Neuroscience, 23 (22); 8077-8091, 2003.
Kemp, P.J., C. Peers & A. Lewis. Oxygen sensing by human recombinant large conductance, calcium-activated potassium channels. Regulation by acute hypoxia. Advances in Experimental Medicine and Biology, 536; 209-215, 2003.
Anantharam, A.*, A. Lewis*. G. Panaghie, E. Gordon, Z.A. McCrossan, D.J. Lerner & G.W. Abbott. RNAi reveals endogenous Xenopus MiRPs govern mammalian K+ channel function in oocyte expression studies. Journal of Biological Chemistry, 278 (14); 11739-11745, 2003.
* These authors contributed equally to this work.
Kemp, P.J., C. Peers, P. Miller & A. Lewis. Oxygen sensing by human recombinant tandem-P domain potassium channels. Advances in Experimental Medicine and Biology, 536; 201-208, 2003.
Peers, C., A. Lewis, L.D. Plant, H.A. Pearson, & P.J. Kemp. O2-sensitive K+ channels controlling cell excitability. In Lung Oxygen Sensing, eds. Lahiri, Semenza & Prabhakar. Pub. Marcel Dekker Inc, New York, Chapter 16; 299-314, 2003.
Kemp, P.J., G.J. Searle, M.E. Hartness, A. Lewis, P. Miller, S. Williams, P. Wootten, D Adriaensen & C. Peers. Acute Oxygen Sensing in Cellular Models: Relevance to the Physiology of Pulmonary Neuroepithelial and Carotid Bodies. The Anatomical Record, (Part A) 270A; 41-50, 2003.
Miller, P., P.J. Kemp, A. Lewis, C.G. Chapman, H.J. Meadows & C. Peers. Acute hypoxia occludes hTREK-1 modulation: re-evaluation of the potential role of tandem P domain K+ channels in central neuroprotection. Journal of Physiology, 548.1, pp 31-37, 2003.
Lewis, A., C. Peers, M.L.J. Ashford, & P.J. Kemp. Hypoxia inhibits recombinant maxi K+ channels by a mechanism which is membrane-delimited and Ca2+-sensitive. Journal of Physiology, 540.3; 771-780, 2002.
Kemp, P.J., A. Lewis, M.E. Hartness, G.J. Searle, P. Miller, I. O’Kelly, & C. Peers. Airway chemotransduction: From oxygen sensor to cellular effector. American Journal of Respiratory and Critical Care Medicine, 166; pp S17-S24, 2002.
Lewis, A., M.E. Hartness, C.G. Chapman, I.M. Fearon, H.J. Meadows, C. Peers, & P.J Kemp. Recombinant hTASK1 is an O2-sensitive K+ channel. Biophysical and Biochemical Research Communications, 285 (5); 1290-1294, 2001.
Hartness, M.E., A. Lewis, G.J. Searle, I. O’Kelly, C. Peers, & P.J. Kemp. Combined antisense and pharmacological approach implicates hTASK as an airway oxygen sensing K+ channel. Journal of Biological Chemistry, 276 (28); 26499-26508, 2001.
O’Kelly, I., A. Lewis, C. Peers and P.J. Kemp. O2-sensing by model airway chemoreceptors: Hypoxic inhibition of K+ channels in H146 cells. Advances in Experimental Medicine and Biology, 475, 611-22, 2000.
O’Kelly, I., A. Lewis, C. Peers, & P.J. Kemp. O2 sensing by airway chemoreceptor-derived cells; protein kinase C activation reveals functional evidence for involvement of NADPH oxidase. Journal of Biological Chemistry, 275 (11); 7684-7692, 2000.