Pharmacy and Biomedical Sciences

Profile

Key Teaching Responsibilities

Level 1:     

• Introduction to Anatomy, Physiology and Pharmacology 
• Key Skills

Level 2:     

• Endocrine and Gastrointestinal Pharmacology
• Respiratory, Renal and Cardiovascular Pharmacology

Level 3:  

• Professional Skills in Pharmacology

Level 4:  

• MSc Biomedicine – Molecular Medicine

Academic Related Duties

• Unit co-ordinator for Year 1 Review Unit
• Deputy Admissions Tutor
• Personal Tutor
• Faculty Recruitment and Retention Committee Representative for SPBMS
• Genetic Modification (GMAG) Committee Representative for SPBMS
• Facilitator for Inter-Professional Learning (IPLU-1)

External Memberships

• The Physiological Society
• The Biophysical Society
• Higher Education Academy (Bioscience)

Research interests

• Ion Channel Research Group
• Mammalian potassium channel structure-function relationships in health and disease 
• Biophysics and physiology of fungal potassium channels

Techniques used in the lab include electrophysiology (two-electrode voltage clamp and patch clamp), molecular biology, microbiology, biochemistry and immunocytochemistry.

Funding/Research Grants

• BBSRC
• Dunhill Medical Trust
• Royal Society 

Recent Publications

Publications before 2008

Cordero-Morales, J.F., V. Jogini, A. Lewis, V. Vasquez, D.M. Cortes, B. Roux & E. Perozo. Molecular driving forces determining potassium channel slow inactivation. Nature Structural and Molecular Biology, 14 (11); 1062-1069, 2007.

Lewis, A., Z.A. McCrossan & G.W. Abbott.  MinK, MiRP1 and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating.  Journal of Biological Chemistry, 279(9); 7884-7892, 2004.

Kemp, P.J., C. Peers, A. Lewis & P. Miller.  Regulation of recombinant human brain tandem P domain K⁺ channels by hypoxia: a role for O₂ in the control of neuronal excitability.  Journal of Cellular and Molecular Medicine, 8 (1); 38-44, 2004.

McCrossan, Z.A., A. Lewis, G. Panaghie, P.N. Jordan, D.J. Christini, D.J. Lerner & G.W. Abbott.  MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain.  Journal of Neuroscience, 23 (22); 8077-8091, 2003.

Kemp, P.J., C. Peers & A. Lewis. Oxygen sensing by human recombinant large conductance, calcium-activated potassium channels. Regulation by acute hypoxia. Advances in Experimental Medicine and Biology, 536; 209-215, 2003.

Anantharam, A.*, A. Lewis*. G. Panaghie, E. Gordon, Z.A. McCrossan, D.J. Lerner & G.W. Abbott.  RNAi reveals endogenous Xenopus MiRPs govern mammalian K⁺ channel function in oocyte expression studies. Journal of Biological Chemistry, 278 (14); 11739-11745, 2003.

* These authors contributed equally to this work.

Kemp, P.J., C. Peers, P. Miller & A. Lewis. Oxygen sensing by human recombinant tandem-P domain potassium channels.  Advances in Experimental Medicine and Biology, 536; 201-208, 2003. 

Peers, C., A. Lewis, L.D. Plant, H.A. Pearson, & P.J. Kemp.  O₂-sensitive K⁺ channels controlling cell excitability. In Lung Oxygen Sensing, eds. Lahiri, Semenza & Prabhakar. Pub. Marcel Dekker Inc, New York, Chapter 16; 299-314, 2003.

Kemp, P.J., G.J. Searle, M.E. Hartness, A. Lewis, P. Miller, S. Williams, P. Wootten,  D Adriaensen & C. Peers.  Acute Oxygen Sensing in Cellular Models: Relevance to the Physiology of Pulmonary Neuroepithelial and Carotid Bodies.  The Anatomical Record, (Part A) 270A; 41-50, 2003.

Miller, P., P.J. Kemp, A. Lewis, C.G. Chapman, H.J. Meadows & C. Peers.  Acute hypoxia occludes hTREK-1 modulation: re-evaluation of the potential role of tandem P domain K⁺ channels in central neuroprotection. Journal of Physiology, 548.1, pp 31-37, 2003.

Lewis, A., C. Peers, M.L.J. Ashford, & P.J. Kemp.  Hypoxia inhibits recombinant maxi K⁺ channels by a mechanism which is membrane-delimited and Ca²⁺-sensitive.  Journal of Physiology, 540.3; 771-780, 2002.

Kemp, P.J., A. Lewis, M.E. Hartness, G.J. Searle, P. Miller, I. O’Kelly, & C. Peers.  Airway chemotransduction: From oxygen sensor to cellular effector.  American Journal of Respiratory and Critical Care Medicine, 166; pp S17-S24, 2002.

Lewis, A., M.E. Hartness, C.G. Chapman, I.M. Fearon, H.J. Meadows, C. Peers, & P.J Kemp.  Recombinant hTASK1 is an O₂-sensitive K⁺ channel.  Biophysical and Biochemical Research Communications, 285 (5); 1290-1294, 2001.

Hartness, M.E., A. Lewis, G.J. Searle, I. O’Kelly, C. Peers, & P.J. Kemp.  Combined antisense and pharmacological approach implicates hTASK as an airway oxygen sensing K⁺ channel. Journal of Biological Chemistry, 276 (28); 26499-26508, 2001.

O’Kelly, I., A. Lewis, C. Peers and P.J. Kemp. O₂-sensing by model airway chemoreceptors: Hypoxic inhibition of K⁺ channels in H146 cells. Advances in Experimental Medicine and Biology, 475, 611-22, 2000.

O’Kelly, I., A. Lewis, C. Peers, & P.J. Kemp.  O₂ sensing by airway chemoreceptor-derived cells; protein kinase C activation reveals functional evidence for involvement of NADPH oxidase.  Journal of Biological Chemistry, 275 (11); 7684-7692, 2000.