Pharmacy and Biomedical Sciences

Profile

Academic Duties

Level 1: Cells to Systems; Introduction to Laboratory Research; Graduate Skills

Level 2: Research Methods; Biomedical Toolbox

Level 3: Integrated Pathology; Genetic Basis of Disease; Clinical Research in Integrated Medicine

Level M: Integrated Pathology; Scientific Methods

Undergraduate tutor

Supervision of research projects at Undergraduate level

Supervision of a Ph.D and two Profesional Doctorate students

Research Interests

In characterising the physiological and pathophysiological bladder, and the transition in between, my research aims to provide better treatments for common, debilitating diseases of the urinary tract. The tools we use are wide-ranging: from molecular biology, electrophysiology and calcium imaging to characterise signalling between cells and tissues, to measures of bladder function in human subjects.

Research Funding

Principal Investigator. Age UK. 01 Oct 2010 – 31 Mar 2013. £163,641.

Principal Investigator. Rosetree’s Foundation. 01 Oct 2010 – 30 Sept 2012. £10,000.

Co-investigator. Boston Scientific. 01 Nov 2011 – TBC. £45,153.

Co-investigator. Takeda. 01 Apr 2011 – 31 Dec 2011. £40,991.

Co-investigator. EU FP7. 01 Dec. 2008 – 30 Nov 2011. £249,66.

Co-investigator. Pfizer. 01 July 2008 – 31 Dec 2010. £43,056.

Other responsibilities

• I have reviewed manuscripts for: Nature Reviews Urology; British Journal of Pharmacology; International Urogynecology; Journal of Applied Physiology; Experimental Physiology; Annals of Biomedical Engineering.
• Member of the International Consultation on Incontinence.
• Visiting Lecturer at the Universities of Oxford and Surrey.
• Co-founder of Young Urology Meeting (www.young-urology.org).

Publications

Peer-reviewed research

1. Young JS, Johnston L, Soubrane C, McCloskey KD, McMurray G, Eccles R, Fry CH. The passive and active contractile properties of the neurogenic, underactive bladder. British Journal of Urology International. In Press.
2. Fry CH, Young JS, Jabr RI, McCarthy C, Ikeda Y, Kanai AJ. Modulation of spontaneous activity in the overactive bladder - the role of P2Y agonists. American Journal of Physiology. 302(11):F1447-54.
3. Young JS, Matharu R, Carew MA, Fry CH. Inhibition of stretch-evoked ATP release from bladder mucosa by anti-cholinergic agents. British Journal of Urology International. In Press.
4. Meng E, Young JS, Cha TL, Sun GH, Yu DS, Brading AF. Neuronal-derived Nitric Oxide Modulates the Activity of Mouse Detrusor Smooth Muscle. Neurourology and Urodynamics. In Press.
5. Johnston L, Cunningham RMJ, Young JS, Fry CH, McMurray G, Eccles R, McCloskey KD. Altered distribution of interstitial cells and innervation in the rat urinary bladder following spinal cord injury. Journal of Cellular and Molecular Medicine. In Press.
6. Kobayter S, Young JS, Brain KL. (2012). Prostaglandin E₂ induces spontaneous rhythmic activity in mouse urinary bladder independently of efferent nerves. British Journal of Pharmacology 165:401-13.
7. Fry CH, Bayliss M, Young JS, Hussain M. (2011). The influence of age and bladder dysfunction on the contractile properties of isolated human detrusor smooth muscle. British Journal of Urology International 108:E91-6.
8. Valeri A, Brain KL, Young JS, Sgaragli G, Pessina F. (2009). Effects of 17β-estradiol on rat detrusor smooth muscle contractility. Experimental Physiology 94:834-846.
9. Young JS, Amos RJ, Brain KL. (2009). Focal Ca²⁺ transient detection in smooth muscle. Journal of Visualized Experiments 28.
10. Young JS, Meng E, Cunnane TC, Brain KL. (2008). Spontaneous purinergic neurotransmission in the mouse urinary bladder. Journal of Physiology 586: 5743-5755.
11. Zhu H-L, Brain KL, Aishima M, Shibata A, Young JS, Sueishi K, Teramoto N. (2008). Actions of Two Main Metabolites of Propiverine (M-1 and M-2) on Voltage-Dependent L-Type Ca²⁺ Currents and Ca²⁺ Transients in Murine Urinary Bladder Myocytes. Journal of Pharmacology and Experimental Therapeutics 324: 118-127.
12. Meng E, Young JS, Brading AF. (2008). Spontaneous activity of mouse detrusor smooth muscle. Neurourology and Urodynamics 27(1): 79-87
13. Young JS, Brain KL, Cunnane TC. (2007). On electrically-evoked neurotransmission in mouse isolated vas deferens smooth muscle. Neuroscience 148: 82-91.
14. Young JS, Brain KL, Cunnane TC. (2007). The origin of the skewed amplitude distribution of spontaneous excitatory junction potentials in poorly coupled smooth muscle cells. Neuroscience 145: 153-161.
15. Huang WC, Young JS, Glitsch MD. (2007). Changes in TRPC channel expression during postnatal development of cerebellar neurons. Cell Calcium 42: 1-10
16. Young JS, Peck LS, Matheson T. (2006). The effects of temperature on walking and righting in temperate and Antarctic crustaceans. Polar Biology 29: 978-987.
17. Young JS, Peck LS, Matheson T. (2006). The effects of temperature on peripheral neuronal function in eurythermal and stenothermal crustaceans. Journal of Experimental Biology 209: 1976-1987.
18. Young J (2002). Physiological control of behaviour at low temperatures. Physiology News 49 18.

Review articles

1. Madersbacher H, Cardozo L, Chapple C, Abrams P, Toozs-Hobson P, Young JS, Wyndaele JJ, De Wachter S, Campeau L, Gajewski JB. (2012). What are the causes and consequences of bladder overdistension? ICI-RS 2011. Neurourol Urodyn. 31(3):317-21.
2. Fry CH, Young JS. (2010). The physiology and pharmacology of the lower urinary tract. Surgery 28: 317-322.
3. Fry CH, Meng E, Young JS. (2009). The physiological function of lower urinary tract smooth muscle. Autonomic Neuroscience 154:3-13.

Book chapters

1. Fry CH, Chacko S, Chess-Williams R, de Wachter S, Kanai AJ, Takeda M, Young JS. Committee 2 report – Cell Biology. (2012). In: Abrams P, Cardozo L, Khoury S, Wein A. Incontinence 5th Edition. In Press.

Patent applications

1. Nagale S, Cheng R, Sherry J, Borzelleca D, Fry CH, Young JS, Hague T. Methods and Systems for Detection and Thermal Treatment of Bladder Overactivity. Filed 30 Mar 2012.