Faculty of Science

Profile

Profile

I am currently the Learning Support Tutor for the faculty of Science. Appointed in 2011, I have previously been involved in teaching science based subjects in a number of Universities in the UK.  At Brunel University (1994 -1999) I contributed seminar workshops and tutorials to the B.Sc. Medical Biochemistry and M.Sc. Medical Molecular Biology courses, supervised undergraduate and postgraduate research projects. At Imperial College London, in the Oncology Department (currently Department of Surgery and Cancer), I delivered lectures on the B.Sc. Biochemistry and the M.Sc. Molecular Medicine courses and tutorials on the M.Sc. Medical Genetics course (1999 – 2007). I also supervised the projects of many M.Sc. and Ph.D. students at Imperial College.

My background is in molecular biology, particularly DNA responses to environmental factors and prostate cancer research. I have worked as a research scientist at Brunel University and Imperial College London. Projects based on my work have attracted funding from AICR (two awards), The Prostate Cancer Charity UK (3 awards), NTRAC (2 awards) and I have been co-author on 5 successful funding bids, resulting in £630,000 funding. I was also awarded funding of £40,000 as P.I. to employ a research assistant from the British Prostate Research Campaign UK.

I am currently a member of AldinHE

Publications:

Brooke GN, Culley RL, Dart DA, Mann DJ, Gaughan L, McCracken SR, Robson CN, Spencer-Dene B, Gamble SC, Powell SM, Wait R, Waxman J, Walker MM, Bevan CL. “FUS/TLS is a novel mediator of androgen-dependent cell-cycle progression and prostate cancer growth.” Cancer Res. 2011 Feb 1;71(3):914-24.

Dart DA, Spencer-Dene B, Gamble SC, Waxman J, Bevan CL. ”Manipulating prohibitin levels provides evidence for an in vivo role in androgen regulation of prostate tumours.” Endocr Relat Cancer. 2009 Dec;16(4):1157-69.

G.Chang, S.C.Gamble, M.Odontiadis, M.Jhamai, R.Wait, C.L.Bevan, A.O. Brinkmann. “Proteomic analysis of proteins regulated by TRPS1 transcription factor in DU145 prostate cancer cells” Biochim Biophys Acta. 2007 May;1774(5):575-82.

S.C.Gamble, M.Odontiadis, D.Chotai, G.N.Brooke, S.Powell, V.Reebye, A. Varela-carver, J.Waxman, C.L.Bevan. “Prohibitin represses androgen receptor mediated transcription in hormone sensitive cancer cells” Oncogene (2007)

S.M. Powell, G.N. Brooke, H.C. Whitaker, V. Reebye, S.C. Gamble, D. Chotai, D.A. Dart, B. Belandia, C.L. Bevan, “Mechanisms of androgen receptor repression in prostate cancer” 34(6) 1128-1131, Biochem. Soc. Trans. (2006)

O.Teahan, S.C.Gamble, E.Holmes, J.Waxman, J.K.Nicholson, C.L.Bevan, H.Keun. “The impact of analytical bias in the metabonomic studies of human blood serum and plasma” Analytical Chemistry 78 (13), 4307-4318, (2006)

J.P.Alao, S.C.Gamble, A.V.Stavrapolou, K.M.Pomeranz, E.W.-F.Lam, R.C.Coombes, D.M.Vigushin. “The cyclin D proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines”  Molecular Cancer 5:7, (2006)

Simon C. Gamble, Michael Odontiadis, Jonathan Waxman, Jules A. Westbrook, Michael J. Dunn, Robin Wait, Charlotte L. Bevan. “Androgens target prohibitin to regulate proliferation of prostate cancer cells”Oncogene, 23, 2996-3004, (2004), Impact factor

Whitaker HC, Hanrahan S, Totty N, Gamble SC, Waxman J, Cato AC, Hurst HC, Bevan CL. “Androgen receptor is targeted to distinc subcellular compartments in response todifferent therapeutic antiandrogens” Clin Cancer Res. 21, 7392-7401, (2004)

S.C.Gamble, M.J.Dunn, C.H.Wheeler, M.C.Joiner, A.Adu-Poku, J.E.Arrand, “Expression of proteins co-incident with inducible radioprotection in human lung epithelial cells” Cancer Research, 60, 2146-2151, (2000)

Janet E Arrand, Anita Adu-Poku, Stewart C Fawell, Michael J Dunn and Simon C Gamble. “Response of human cells to electromagnetic fields: do effects vary with genetic background?” Radiation Research, 2 (Proceedings) 244-247 (2000).

S.C.Gamble, Z.Herceg, A.Riches, P.Bryant, M.Cook, J.E.Arrand, "Investigation of ras and p53 mutations in tumours derived from irradiated human thyroid epithelial cells." Mutation Research, 425, 231-238, (1999)

H.Wolff, S.Gamble, T.Barkley, L.Janaway, F.Jowett, J.A.T.Halls, J.E.Arrand, “The design, construction and calibration of a carefully controlled source for exposure of mammalian cells to extremely low-frequency electromagnetic fields” Journal of Radiological Protection, 19, 231-242 (1999)

S.Gamble, H.Wolff, J.E. Arrand, “Syrian Hamster dermal cell immortalisation is not enhanced by power line frequency electromagnetic field exposure”British Journal of Cancer, 81, 377-380,(1999)

S.Colucci, C.Mothersill, J.Harney, S.C.Gamble, C.Seymour and J.E.Arrand, "Induction of multiple PCR-SSCPE mobility shifts in p53 exons in cultures of normal human urothelium exposed to low dose gamma radiation" International Journal of Radiation Biology,72, 21-31 (1997)

J.E.Arrand, B.Singh, T.Robson, S.C.Gamble and M.C.Joiner, "Molecular dissection of X-ray induced responses in humans" Les Editions de Physique, Numero Special de Radioprotection, 32, 311-314 (1997)

A.Riches, Z.Herzeg, P.Bryant, M.Armitage, S.Gamble, J.Arrand, S.O'Reilly, C.Seymour, C.Mothersill, "Radiation induced carcinogenesis: Studies using human epithelial cells" Radiation Oncology Investigations, 5, 139-143 (1997)

S.C.Gamble, P.S.Goldfarb, A.Wiseman. "Glutathione peroxidase and other selenoproteins; their synthesis and biochemical roles" Journal of Chemical Technology and Biotechnology, 68, 123-134 (1997)

S.C.Gamble, P.S.Goldfarb, C.Porte, D.R.Livingstone, "Glutathione peroxidase and other antioxidant enzymes in marine invertebrates", Marine Environmental Research. 39, 191-195 (1995)

Book Chapter:

“Proteomic approaches to problem solving in prostate cancer” S.C.Gamble pp95-103, in “Urological cancers: Science and treatment” Ed. Waxman J. Springer-Verlag London Ltd. (2005)