Institute of Biological and Biomedical Sciences
Numerous biochemical, biophysical and molecular biological techniques are employed to investigate both structural and functional aspects of macromolecular interactions. State-of-the-art biophysical facilities include an X-ray Diffractometer with Cryojet (Oxford Diffraction / Agilent), a Cartesian crystallisation robot, a 600MHz NMR spectrometer with cryo-probe (Varian / Agilent), Analytical Ultracentrifugation (Beckman XL-A), Surface Plasmon Resonance (BiaCoreT200), Circular Dichroism and Fluorescence Spectroscopy, Laser Light Scattering (both DLS and MALLS) and Calorimetry (ITC and DSC).
This is complemented by extensive facilities for bacterial growth and protein purification. We also have access to confocal microscopes, atomic force microscopes and electron microscopes within IBBS. In addition, we have good access to facilities for Synchrotron Radiation at the Diamond Light Source (Harwell) and ESRF (Grenoble); Neutron Scattering facilities at Institute Laue-Langevin (Grenoble) and protein expression facilities at OPPF (Harwell).