Institute of Biomedical and Biomolecular Science (IBBS)

RECENT PUBLICATIONS:

  1. Beręsewicz M, Majewska M, Makarewicz D, Vayro S, Zabłocka B, Górecki DC. Changes in the expression of Insulin-like Growth Factor 1 variants in the postnatal brain development and in neonatal hypoxia-ischaemia. Int. J. Devl. Neuroscience 28: 91–97, 2010.
  2. Nicke A, Kuan Y-H, Masin M, Rettinger J, Marquez-Klaka B, Bender O, Górecki DC, Murrell-Lagnado R, Soto F. A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 KO mice. J Biol Chem. 284(38):25813-22, 2009.
  3. Onopiuk M, Brutkowski W, Wierzbicka K, Wojciechowska S, Szczepanowska J, Fronk J, Lochmüller H, Górecki DC, Zabłocki K. Mutation in dystrophin-encoding gene affects energy metabolism in mouse myoblasts Biochem. Biophys. Res. Com. 386(3): 463-466, 2009.
  4. Boumechache M, Masin M, Edwardson JM, Górecki DC, Murrell-Lagnado R. Analysis of assembly and trafficking of native P2X4 and P2X7 receptor complexes in rodent immune cells. J Biol Chem. May 15; 284(20):13446-54. 2009(5.013)
  5. Lavigne MD, Yates LL, Coxhead P, Górecki DC. Nuclear-targeted chimeric vector enhancing non-viral gene transfer into skeletal muscle of Fabry mice in vivo. FASEB J. 22(6):2097-2107, 2008.
  6. Hamilton N, Vayro S, Kirchhoff F, Verkhratsky A, Robbins J, Górecki DC, Butt AM. Mechanisms of ATP- and glutamate-mediated calcium signalling in white matter astrocytes. Glia 56 (7): 734-49, 2008.
  7. Wilczynski GM, Konopacki FA, Wilczek E, Lasiecka Z, Gorlewicz A, Michaluk P, Wawrzyniak M, Malinowska M, Okulski P, Kolodziej LR, Konopka W, Duniec K, Mioduszewska B, Nikolaev E, Walczak A, Owczarek D, Górecki DC, Zuschratter W, Ottersen OP, Kaczmarek L. Important role of matrix metalloproteinase 9 (MMP-9) in epileptogenesis. J. Cell Biol. 180 (5):1021-35, 2008
  8. Hazai D, Lien C-F, Hajos,F, Halasy K, Górecki DC, Jancsik V. Synaptic expression of alpha-dystrobrevin: localisation of a short alpha-dystrobrevin isoform in melanin-concentrating hormone neurons of the hypothalamus. Brain Res., 1201: 52-9, 2008.
  9. Michaluk P, Kolodziej L, Mioduszewska B., Wilczynski G M, Dzwonek J., Jaworski J., Górecki DC Ottersen OP, Kaczmarek L. Beta-dystroglycan as a target for MMP-9 in response to enhanced neuronal activity. J. Biol. Chem, 282: 16036 – 16041, 2007.
  10. Pennadam SS, Ellis JS, Lavigne MD, Górecki DC Davies MC, Alexander C. Synthesis and characterization of variable architecture thermo-sensitive polymers for complexation with DNA . Langmuir, 23(1):41-49, 2007.
  11. Lien C.F, Hazai D, Yeung D, Tan J, Fuchtbauer E-M, Jancsik V, Górecki D.C. Expression of alpha-dystrobrevin in blood-tissue barriers: sub-cellular localisation and molecular characterisation in normal and dystrophic mice. Cell Tissue Res., 327(1):67-82, 2007.
  12. Lavigne MD, Pennadam SS, Ellis J, Yates LL, Alexander C, Górecki DC. Enhanced gene expression through temperature profile-induced variations in molecular architecture of thermoresponsive polymer vectors. J Gene Med., 9(1):44-54, 2006.
  13. Yeung D, Zablocki K, Lien C-F, Jiang T, Arkle S, Brutkowski W, Brown J, Lochmuller H, Simon J, Barnard E.A, Górecki D.C. Increased susceptibility to ATP via alteration of P2X receptor function in dystrophic mdx mouse muscle cells. FASEB J. 20(6): 610-20, 2006.
  14. Zeng Z, Sharpe C.R, Simons J.P, Górecki DC. The expression and alternative splicing of alpha-neurexins during Xenopus development. Int. J. Dev. Biol., 50(1): 39-46, 2006.
  15. Dłużniewska J, Sarnowska A, Beręsewicz M, Johnson I, Srai S.K.S, Ramesh B, Goldspink G, Górecki D.C., Zabłocka B. A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischaemia. FASEB J. 2005, 19(13):1896-8.
  16. Lavigne MD, Pohlschmidt M, Novo FJ, Higgins B, Alakhov V, Lochmuller H, Sakuraba H, Goldspink G, MacDermot K and Górecki DC. Promoter-dependence of plasmid-pluronics targeted alpha-galactosidase a expression in skeletal muscle of Fabry mice. Molecular Therapy, 2005, 12(5): 985-90.
  17. Jiang T, Yeung D, Lien C-F, and Górecki D.C. Localized expression of specific P2X receptors in dystrophin-deficient DMD and mdx muscle. Neuromuscular Dis., 15: 225–236, 2005.


Review papers:

  1. Barbu E, Molnàr E, Tsibouklis J, Górecki DC. The potential for nanoparticle-based drug delivery to the brain: overcoming the blood-brain barrier. Expert Opin Drug Deliv. 2009; 6(6):553-65.
  2. Górecki DC, Beręsewicz M and Zabłocka B. Neuroprotective effects of short peptides derived from the Insulin-like Growth Factor. Neurochem Int. 2007;
  3. Rees MLJ, LienC-F and Górecki DC. Dystrobrevins in muscle and non-muscle tissues. Neuromuscular Disorders. 17(2):123-34, 2007.
  4. Górecki DC. “Dressing-up” naked plasmids: Emerging non-viral gene therapy vectors. Discovery Medicine, 6(35): 191-197, 2006.
  5. Lavigne MD and Górecki DC. Emerging vectors and targeting methods for non-viral gene therapy. Expert Opin. Emerging Drugs. 11(3): 541-57, 2006.

Updated Feb 2010