Institute of Biomedical and Biomolecular Science (IBBS)

2004

  • Molecular Pathways Controlling Neuronal Specification In The Embryonic Vertebrate Brain. £243,340 to Dr F. Schubert (BBSRC). 2004-2007
  • The Control And Molecular Mechanism Of Wood Digestion In Limnoria. £110,040 to Dr S. Cragg and Dr M. Guille (The Leverhulme Trust). 2004-2007
  • The Role Of Prostaglandins In The Regulation Of Fibrin Formation And Bronchial Epithelial Repair. £98,143 to Dr J. Shute (Pfizer). 2004-2006
  • Novel intracellular neutrophil elastase. £65,809 to Dr J. Shute (Cystic Fibrosis Trust) 2004-2007
  • Bedscapes. £143,381 to Prof. T. Dean (Dunhill Medical Trust). 2004-2006

2003

  • A pragamatic parallel, RCT to investigate the efficacy of natural scene photomurals combined with associated sounds of nature in reducing pain and anxiety during minor surgery and wound management in community based clinics. £143,381 to Prof. T. Dean and Prof. M. Severs (Dunhill Medical Trust). 2003-2006
  • Structural Basis of Gene regulation in a novel restriction - modification system. £208,452 to Prof. G. Kneale (BBSRC) 2003-2006
  • A Molecular Magnetic switch that links the biological and silicon worlds. £203,764 to Dr K. Firman. (European Commission) 2003-2005
  • Analysis of the 3 dimensional structure and molecular interactions of Eukaryotic initiation factors. £111,690 to Dr M. Conte (The Wellcome Trust). 2003-2005
  • Molecular Machines in Nanotechnology. £63,053 to Dr K. Firman (EPSRC) 2003-2006
  • Medical and Fitness Standards. £109,485 to Prof. M. Tipton (RNLI) 2003-2005
  • Role of matrix metalloproteinases in remodelling synaptic connections. £97,460 to Prof. D. Gorecki (Wellcome Trust) 2003-2006
  • Evaluation of the efficacy of Clomipramine in treatment of malignant glioma. £260,000 to Prof. G. Pilkington (Samantha Dickson Research Trust). 2003-2006
  • Efficacy Of Oral Fish Oil Capsules In Preventing The Development Of Cachexia in Patients With Untreatable Cancer.
  • £169,471 to Dr A. Dewey (Department of Health). 2003-2006
  • An Investigation Into Trends Of Peanut Allergy Incidences In The Last 15 Years In England Using Sequential Childhood Cohorts. £115,758 to Prof. T. Dean (Food Standards Agency) 2003-2006
  • Novel Data Analysis Techniques for High Throughput Screening. £137,000 to Prof. M. Ford (ICI) 2003-2005.
  • Paradigm for virtual screening. £103,121 to Prof. M. Ford (EPSRC) 2003-2004

2002

  • An investigation into trends of peanut allergy incidence in the last 15 years in England using sequential childhood cohorts; £115,758 to Prof. T. Dean (Food Standards Agency). 2002-2005
  • Structure and Function of the Methyltransferase M.AhdI. £157,000 to Prof. G. G. Kneale. (Wellcome Trust). 2002-2005.
  • Deuteration Initiative for Biological Neutron Scattering and NMR. £1,000,000 to Prof. G. G. Kneale and collaborators. (EPSRC) 2002-2005
  • "Trojan Horse" - nano-scale packaging, separation and delivery device. £125,000 to Dr D. Gorecki, Dr C. Alexander, Dr D. Mernagh & Dr K. Firman. (Wellcome Trust) 2002-2005.
  • A molecular magnetic switch that links the biological and silicon worlds. £1,974,000 to Dr K. Firman and collaborators (EU). 2003-2006.
  • NETWORK: Molecular machines in nanotechnology. £63,053 to Dr K. Firman and collaborators (EPSRC). 2003-2006.
  • "Molecular and Functional Analysis of Neurexins in Xenopus Primary Neurone Synaptogenesis" £189,000 to Dr D. Gorecki, Dr C. Sharpe & Dr J.P. Simons. (Wellcome Trust) 2002-2005.
  • "The roles of RNA turnover and protein modification in the control of subcellular localisation of a maternal Xenopus transcription factor". (Wellcome Trust) £190,818 to Dr M. Guille & Dr A. Thorne. 2002-2005.
  • Lipopolysaccharide binding serum proteins. £190,000 to Dr K. Triantafilou. (BBSRC) 2001-2004.
  • Investigation into the mechanisms of bacterial septicemia. £65,000 to Dr K. Triantafilou. (Sports Aiding Medical Research for Kids). 2002-2004.
  • Analysis of the LPS supramolecular activation cluster. £205,000 to Dr K. Triantafilou. (Wellcome Trust). 2002-2005.
  • Epithelial pro-coagulant activity: a determinant of bronchial epithelial repair in asthma. £85,000 to Dr J. Shute. (National Asthma Campaign). 2002-2004.
  • NMR studies to evaluate the microscopic bases of the thermodynamic forces driving the binding of proteins to the major and the minor grooves of DNA. £197,832 to Prof. C. Crane-Robinson, Dr M. Conte & Dr C. Read. (Wellcome Trust) 2002-2005.
  • Analysis of the 3-dimensional structure and molecular interaction of eukaryotic initiation factor 5 (eIF5). £111,690 to Dr M. Conte in collaboration with Prof. Christopher Proud, University of Dundee. (Wellcome Trust) 2002-2005.
  • Standardised Aquatic Monitoring with Passive Sampling. £875,000 to Dr R. Greenwood, Dr G. Mills. and partners (EU Fifth Framework Programme) 2003-2005

2001

  • Prevalence and incidence of food allergy and intolerance - A prospective cohort study. £603,605 to Prof. T. Dean (Food Standards Agency). 2001-2006
  • Identification and characterisation of novel acetyltransferases from chicken erythrocytes. £190,000 to Dr T Hebbes. (Wellcome Trust). 2001-2004.
  • Examination of the links between dysglycaemia, oxidative stress and the vascular endothelium. £20,000 to Dr D.W. Laight. (NHS-Academic Research Development Fund). 2001-2002.
  • Controlled release systems. £91,000 to Dr J. Tsibouklis. (S.C. Johnson). 2001-2003.
  • Mechanisms of Coxsackie B4 virus mediated IDDM. £120,000 to Dr M Triantafilou & Dr K Triantafilou. (Diabetes UK). 2001-2004.
  • Gram-negative sepsis. £10,000 to Dr K Triantafilou. (Royal Society) 2001-2002.
  • The role of chromatin structure and DNA methylation in transcriptional repression by (CGG)n repeats. £179,774 to Dr S. Chandler. (BBSRC) 2001-2004.
  • Breast Cancer Studies. £66,000 to Prof. C. Crane-Robinson and Prof. Mike Perry. (Portsmouth Hopsitals NHS Trust). 2001-2002.
  • Investigating the formation of primary neurones in Xenopus. £172,516 to Dr C. Sharpe. (BBSRC). 2001-2004.
  • Structure-function investigations of La autoantigen. £173,734 to Dr M. Conte and Dr S .Curry (Wellcome Trust). 2001-2004.
  • Modification of bronchial epithelial cell tPA and PAI-1 synthesis and release by PDE inhibitors. £38,000 to Dr J. Shute. (Byk Gulden). 2001- 2001.
  • Factors influencing repair of epithelial cells from bronchial tissue. £94,620 to Dr. J. Shute. (Pfizer). 2001- 2004.
  • Mucoadhesive colon-specific drug delivery systems. £98,084 to Dr. J. Tsibouklis and Dr. J. Smart. (BBSRC). 2001-2003.
  • Fluorosilicones with resistance to biological fouling. £44,000 to Dr. J. Tsibouklis, Dr. T. Nevell, Dr. E. Barbu and Dr R. Fletcher. (Dow Corning). 2001-2005.
  • The low surface energy approach to antifouling. £38,000 to Dr. J. Tsibouklis, Dr. T. Nevell, Dr. E. Barbu and Dr R. Fletcher. (NERC). 2001-2004.

2000

  • Spectrofluorimetric studies of DNA distortion induced by Protein binding. £84,912 to Prof. C. Crane-Robinson, Prof. G.G. Kneale and Dr A.I. Dragan (Wellcome Trust) 2000-2004.
  • The regulation of chemokine and growth factor function in cystic fibrosis. £285,000 to Dr J. Shute. (Cystic Fibrosis Trust). 2000-2003.
  • Towards the Rational Design of Templated Surfaces. £242,702 to Dr C. Alexander. (EPSRC). Advanced Research Fellowship 2000-2005.
  • Hydrophilic polymers as biofouling release agents (II). £42,000 to Dr. J. Tsibouklis and Dr. J. Smart. (S.C. Johnson). 2000-2001.
  • Mapping surface heterogeneity of polymer blends: an adhesion-force-distribution study using the atomic force microscope. £91,366 to Dr. J. Smart and Dr. J. Tsibouklis. (EPSRC). 2000-2002.
  • Mucoadhesive microparticles for colon-specific drug delivery. £15,680 to Dr. J. Tsibouklis and Dr. J. Smart. (Leverhulme Trust). 2000-2001.
  • Determination of the physical capabilities of firefighter instructors at the end of a hot fire training exercise. £23,000 to Dr Clare Eglin. (Home Office) 2000- 2002.

1999

  • 600MHz NMR Facility for the analysis of Biomolecular Structure. £780,000 to Prof. G. G. Kneale, Prof. C. Crane-Robinson and Dr P. Cary. (Wellcome Trust). 1999-2004.
  • GATA-2 transcription and early development: the role and regulation of p122. £119,791 to Dr M. Guille and Dr A. W. Thorne. (Wellcome Trust). 1999 - 2001.
  • The role of Nucleosome Assembly Protein 1 in haematopoiesis. £162,192 to Dr M. Guille and Dr A. W. Thorne (with Prof R. Patient, Nottingham). (BBSRC) 1999-2001.
  • Cloning and Characterisation of a 32 kDa Chicken Histone Acetyltransferase. £51,000 to Dr T. Hebbes. (Wellcome Trust). 1999-2000.
  • An unusual restriction-modification system of the simple prokaryote Mycoplasma pulmonis. £87,587 to Dr.K. Firman (Wellcome Trust) 1999-2001.
  • Molecular techniques for the detection of breast cancer. £47,000 to Prof. C. Crane-Robinson. with Prof M. Perry, Post Graduate Medical School (Dunhill Medical Trust) 1999-2001.
  • FRC crew fatigue and performance. £190,000 to Prof. M.J. Tipton (Health and Safety Executive) 1999-2000.
  • Thermal insulation and survival time. £77,000 to Prof. M. J. Tipton (Ministry of Defence) 1999.
  • Biological Data Mining: a comparison of Neuraal Network and Symbolic Techniques. £113,284 to Prof. M. Ford (BBSRC) 1999-2002.
  • Investigation of the pharmacokinetic behaviour of imidacloprid and related compounds. £100,000 to Prof. M. Ford and Dr R. Greenwood (Bayer) 1999-2001.
  • Hydrophilic polymers as biofouling release agents (I). £32,881 to Dr. J. Tsibouklis and Dr. J. Smart. (S.C. Johnson). 1999-2000.
  • Refurbishment of Laboratories in the Institute of Biomolecular and Biomedical Science. £285,000 to Prof. G. G. Kneale (coordinator). HEFCE (Refurbishment of Research Laboratories Initiative: 50% HEFCE; 50% University of Portsmouth). 1999

1998

  • Targetted and General Acetylation of Core Histones at Active Genes and Loci. £274,261 to Prof. C. Crane-Robinson and Dr A. W. Thorne (Wellcome Trust) 1998-2001.
  • The effect of heparin and heparan sulphate binding on the biological activity of interleukin-12. £158,192 to Dr R. Gibbs (with Dr C. Rider, Royal Holloway). (Wellcome Trust). 1998 -2001.
  • Ocular drug delivery: the formulation of gelling micro- and nano-particulate systems for ophthalmic delivery. £52,000 to Dr Smart and Dr Tsibouklis. (Pfizer ) 1998-2001.
  • The use of lectins as a means of inhibiting microbiological colonisation of the skin. £44,900 to Dr Smart, Prof. Rogers, Dr Gibbs, Dr Carpenter (Johnson & Johnson), 1998-2001.
  • Imaging synthetic biomaterials at the atomic level: method and underlying science. £53,995 ROPA award to Dr Smart and Dr Tsibouklis (EPSRC) 1998-2000.
  • An investigation into adherent and anti-adherent coatings for oral dosage forms. £46,000 Dr Smart and Dr Tsibouklis (BBSRC/ SmithKline Beecham) 1998-2001.
  • An evaluation of retentive polymers within the oral cavity. £20,800 to Dr Smart and Dr Tsibouklis,(SmithKline Beecham) 1998-1999.

1997

  • Structure specific DNA and RNA sequence recognition by the fd gene 5 protein. £155,000. to Prof. G. G.Kneale (Wellcome Trust) 1997 - 2001.
  • Energetics of HMG Box/DNA interactions: £55,500 to Prof. C. Crane-Robinson (Wellcome Trust) 1997 - 1998.
  • Optimising biological efficacy of pesticides. £163,000 to Prof M. Ford and Dr D. Salt (BBSRC) 1997-2000.
  • Inhibiting bacterial adhesion to surfaces. £52,500 to Dr Smart and Dr Tsibouklis (BBSRC / Reckitt & Colman) 1997-2000.
  • Structural and functional analysis of methyl-CpG binding transcriptional repression MeCP2 in association with chromatin. £103,400 to Dr S. Chandler. (Wellcome Trust International Prize Travelling Fellowship). 1997-2000.

1996

  • Structure-function relationships of a novel, developmentally regulated CCAAT box transcription factor. £163,572 to Dr M. J. Guille and Prof. G. G. Kneale (BBSRC) 1996 - 1999.
  • Chromosomal Mapping of Proteins HMG14/17 & HMG1/2 £160,166 to Prof. C. Crane-Robinson (BBSRC). 1996-1999.
  • Screening for Germline Mutations in Familial Breast Cancer Patients. £38,684 to Prof. C. Crane-Robinson and Prof. Mike Perry. (South & West Regional Health Authority, NHS.) 1996- 1997.
  • The effects of glycosylation on the biological activity of interleukin-7 (IL-7) £61,336 to Dr R. Gibbs (Wellcome Trust) 1996-1999.
  • Study of DNA topology in thermophiles & archaebacteria & its functional consequences. £46,334 to Dr K. Firman and Dr J. McClellan (Wellcome Trust) 1996-1998.
  • Development of passive sampling devices for monitoring the aquatic environment. £115,238 to Dr R. Greenwood and Dr G. Mills (EU) 1996-1999.
  • Analysis of CNG tracts. £89,000 to Dr J. McClellan (NHS) 1996-2000.
  • The effects of cold water immersion on individual respiratory variables and the performance of breathing aids when used in cold water. £50,000 to Prof. M. J. Tipton (Ministry of Defence) 1996.
  • Analysis of the dystrophin complex in the brain. £216,323 to Dr D. Goreki (Wellcome Trust Career Development Fellowship) 1996-2000.
  • The development of new "slippery-surface" materials to prevent biofilm establishment during food manufacture and processing. £293,968 to Dr C. Alexander. (BBSRC / Inst. Of Food Research, Reading Laboratory.) 1996-1999.

1995

  • Equipment for the analysis of molecular interactions between biological macromolecules. £63,400 to Prof. G.G. Kneale and Prof. C. Crane-Robinson. (Wellcome Trust) 1995 - 1998.
  • Role of Core Histone Acetylation in Gene Regulation. £125,797 to Prof. C. Crane-Robinson (Wellcome Trust) 1995 - 1998.
  • Structure and Function of the Chromosomal Activator Protein HMG1. ECU 40 000 to Prof. C. Crane-Robinson. Joint project with colleagues in St. Petersburg, Kiev and Tibilisi. INTAS (European Community) 1995-1998.
  • The Role of Core Histone Acetylation in Eukaryotic Gene Regulation. £277,000 to Dr T. Hebbes. (Wellcome Trust). Career Development Fellowship. 1995-1999.
  • Structural studies of the Methyltransferase M.EcoR124I and its interaction with DNA. £124,000 to Prof. G. G. Kneale (Wellcome Trust) 1995 - 1999.
  • Structure and interactions of the Gene Regulatory Protein AreA of Aspergillus Nidulans. £169,000 to Prof. G.G. Kneale (BBSRC). 1995 - 1999.
  • Isolation and characterisation of an unusual restriction-modification system from Mycoplasma pulmonis. £32,658 to Dr K. Firman (MRC) 1995-1996.
  • Drug Design Initiative. £300,000 to Prof. M. Ford and Dr D. Salt (BBSRC) 1995-1998.
  • Topological descriptors of molecular properties. £134,000 to Prof. M. Ford (BBSRC ROPA) 1995-1997.

1994

  • Structure of a DNA/HMG Box Complex. £143,000 to Prof. C. Crane-Robinson (Wellcome Trust) 1994 - 1997.
  • Initial events in the formation of the Xenopus nervous system. £363,225 to Dr C. Sharpe (MRC Senior Fellowship) 1994-1999.
  • Investigation of how protein-protein interactions influence subunit assembly and cellular localisation of EcoR1241. £57,518 to Dr K. Firman (Wellcome Trust) 1994-1997.