School of Biological Sciences

Staff

Photo of Professor Anastasia J. Callaghan

Professor Anastasia J. Callaghan

  • Role Title: Professor of Biochemistry & Molecular Biophysics/Co-Director- Institute of Biomedical & Biomolecular Science
  • Address: King Henry Building, King Henry 1st Street, Portsmouth, PO1 2DY
  • Telephone: 023 9284 2055
  • Email: anastasia.callaghan@port.ac.uk
  • Department: School of Biological Sciences
  • Faculty: Faculty of Science

Biography

I completed a BSc(Hons) in Biology with Chemistry at the University of Southampton before going on to complete a PhD with Prof Sir Howard Dalton FRS at the University of Warwick. This work focused on the biochemical and structural characterisation of bacterial protein complexes.

I then moved to the University of Cambridge to take up a Wellcome Trust postdoctoral position with Prof Ben Luisi where I worked on the structural and functional characterisation of proteins involved in RNA processing and degradation. During my time at Cambridge I was elected to Senior Membership of Wolfson College and taught biochemistry to medical and veterinary students at Queen’s College.

I subsequently joined Pfizer Global Research & Development as a Principal Scientist (Biophysics) within the Discovery Department’s Structural Biology Group. Contributing to multiple therapeutic areas, I led a focused team in conducting fundamental research in early stage drug discovery. This work gave me an invaluable insight into the applicability of academic research to pharmaceutical development.

I subsequently joined the University of Portsmouth, taking up a tenured Senior Fellowship before being promoted to Principal Fellow and Reader in Biochemistry & Molecular Biophysics. Although I hold a research-focused role, I actively support the teaching within the Department as well as holding a number of additional Departmental, Faculty, University and external responsibilities.

For more information about my research please visit my lab page

Teaching Responsibilities

Personal Tutor to undergraduate students

1st and 2nd Years - Study Support Skills Unit including Maths Workshop Demonstrator

1st Year – Experimental Biology Unit - Practical Class Demonstrator

2nd Year – Biomolecular Science Unit – Practical Class Lead

3rd Year Project Supervisor

Lecturer on Postgraduate Courses

Research

I have an active research group focusing on the study of RNA biology, with interests in post-transcriptional gene regulation and developing tools for investigating RNA-based molecular interactions. Specific research interests include:

  • Studying the interplay of non-coding RNAs, an RNA chaperone protein and ribonucleases in the control of gene expression; a novel mechanism linked to pathogenic bacterial virulence.
  • Exploring a communicative link between the enzymatic machinery of RNA degradation and a key metabolite of central metabolism.
  • Identifying chemical inhibitors of antibacterial targets and understanding their mechanism of action.
  • Developing novel technologies for the study of RNA-interactions.
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Research profile

Explore my research profile, publications and activities on the Portsmouth Research Portal

View profile