School of Pharmacy and Biomedical Sciences

Staff

Dr Marisa van Der Merwe

  • Qualifications: BPharm, MSc, PhD
  • Role Title: Senior Lecturer
  • Address: St. Michael’s Building, White Swan Road, Portsmouth, PO1 2DT
  • Telephone: 023 9284 3571
  • Email: marisa.vdmerwe@port.ac.uk
  • Department: School of Pharmacy and Biomedical Sciences
  • Faculty: Faculty of Science

Biography

I graduated with a BPharm (Cum Laude) from the University of Potchefstroom, Republic of South Africa (RSA) in 1998. I then went on to complete an MSc in Pharmaceutics (Cum Laude) which was awarded in 2000 from the University of Potchefstroom, RSA and also registered as a pharmacist with the South African Pharmacy Council. The research for my MSc focused on investigating the in vitro toxicity profile of N-trimethyl chitosan chloride (TMC), a mucosal absorption enhancer used in the delivery of peptide drugs.

Upon completion of my MSc, I was awarded a prestigious Nelson Mandela Scholarship from the University of Leiden in the Netherlands allowing me to do my PhD research in the group of Prof Dr. Hans Junginger in Pharmaceutics at Leiden Amsterdam Center for Drug Research. Prof. Junginger’s laboratory was world renowned for the work done in the delivery of peptide drugs with various mucosal absorption enhancers as well as mucosal vaccination. Work during my studies in Leiden focused on developing solid oral dosage forms for the oral delivery peptide drugs with TMC. I was awarded a PhD from the University of Potchefstroom, RSA, in 2003.

I was appointed in 2003 as a postdoctoral fellow at North West University, South Africa, in collaboration with MeyerZall Laboratories Pty. Ltd. (RSA), to investigate EmzaloidTM Technology as a mucosal vaccine delivery system.

In September 2004 I was appointed as a Lecturer in Pharmaceutics at the University of Portsmouth and was promoted to Senior Lecturer in Pharmaceutics in September 2005.  Apart from my responsibilities as Deputy Head, Division of Pharmaceutical Sciences, lecturing and course design related to the MPharm degree of the University of Portsmouth, I am also involved in several post graduate research projects either as principal investigator or co-supervisor and have been serving on University committees since 2010. My current research is mainly focused in the area of Clinical Pharmaceutics. 

Teaching Responsibilities

  • Deputy Head, Division of Pharmaceutical Sciences
  • Year 3 tutor for the MPharm pathway
  • TurningPoint Audience Response System coordinator
  • Industrial Pharmacy Liaison
  • Teaching contribution on the following unit which includes lectures, workshops, tutorials and laboratory classes:

- Introduction to Formulation (current)
- Pharmaceutical Formulation (current)
- Pharmaceutical Formulation and Quality Assurance (from 2014)
- Design and Advanced Delivery of Drugs (current)
- Design and Advanced Delivery of Drugs in new MPharm degree (from 2015)
- IPL for year 1

  • Supervisor of MPharm final year projects
  • Personal tutor for MPharm tutees level 4 to level 7
  • Member of academic council – from October 2012
  • Academic Staff Representative on the Student’s and General Affairs Committee of the Board of Governors (2010 – 2013)

Research Interests

I have a broad research interest which includes:

  • Clinical Pharmaceutics: a strong collaboration has been established with Southampton University Hospital NHS Foundation Trust (UHS) and more specifically Southampton Pharmacy Research Centre (SPRC). 
  • Chitosan derivatives as absorption enhancers for peptide drug delivery.
  • Mucosal vaccine delivery.
  • The use of carbon nanotubes in drug delivery.
  • The application of electro-spraying and –spinning in drug delivery.

To view more specific details of the research done in collaboration with SPRC please see the Clinical Pharmaceutics Group page.

Publications

View all publications on Parade…

Funding

Starting May 2014 - Chemical And Physical Compatibility Of Continuous Intravenous Drug Infusion Combinations Used In Paediatric Intensive Care – Phase 2 awarded by the Neonatal and Paediatric Pharmacist Group with Andy Fox and Caroline Cole (University Hospitals Southampton NHS Foundation Trust. - £49,403

October 2011 - Chemical And Physical Compatibility Of Continuous Intravenous Drug Infusion Combinations Used In Paediatric Intensive Care awarded by the Neonatal and Paediatric Pharmacist Group with Andy Fox and Caroline Cole (University Hospitals Southampton NHS Foundation Trust. - £41,003

October 2009 - Nebulisation of IV drugs grant awarded by Charlotte Francis May Foundation with A Bevan and G Connett (University Hospitals Southampton NHS Foundation Trust - £3,700

Presentations

  • Cole, C., Fox, A., Van der Merwe, M., Dickson, L., Ball, K., Bevan, A., Hocking, A. Pappachan, J. Chemical and physical compatibility of continuous intravenous drug infusion combinations used in Paediatric Intensive Care. 33rd International Symposium on Intensive Care and Emergency Medicine, Brussels, March 2013.
  • Fox, A. and Van der Merwe, S.M. Chemical and Physical Compatibility of Continuous Intravenous Drug Infusion Combinations used in Paediatric Intensive Care. Neonatal and Paediatric Pharmacists Group annual conference, Liverpool, 2012.
  • Van der Merwe, S.M, Blissett, J, Connett, G.J. and Bevan, A. Nebulisation of vancomycin injection – efficacy of the nebulisation process for pulmonary delivery. Neonatal and Paediatric Pharmacists Group annual conference, Bristol, 2011.
  • Van der Merwe, S.M. Nebulisation of IV injections for inhalation in the treatment of Cystic Fibrosis (CF): A clinical perspective. Informa’s Inhalation Drug Development conference, London, October, 2011.
  • Nazar, H., Fatouros, D.G., Van der Merwe, S.M., Roldo, M. Thermosensitive Hydrogel Formulations containing N-Trimethyl chitosan Chloride for Nasal Drug Delivery. 36th Annual Meeting and Exposition of the Controlled Release Society July 18-22 Copenhagen Denmark, 2009
  • Albader, W.A., Van der Merwe, S.M., Fatouros, D.G. Preparation and Characterization of Trimethyl-chitosan Coated Liposomes. 36th Annual Meeting and Exposition of the Controlled Release Society July 18-22 Copenhagen Denmark, 2009

Collaborations

  • Andy Fox – Director, SPRC, UHS, Southampton.
  • Caroline Cole - SPRC, UHS, Southampton.
  • Dr Amanda Bevan - SPRC, UHS, Southampton.
  • Dr Gary Connett – UHS, Southampton.
  • Dr Zeeshan Ahmad – Leicester School of Pharmacy, De Montford University, Leicester.
  • Dr Dimitris Fatouros - School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Prof. AF Kotzé – Dean, Faculty of Health Sciences, North-West University, South Africa.

Postgraduate Research Supervised

  • DICKSON, L. Chemical And Physical Compatibility Of Continuous Intravenous Drug Infusion Combinations Used In Paediatric Intensive Care. Postdoctoral Researcher, Oct 2012 – October 2013.
  • NAZAR, H. Thermosensitive hydrogels for nasal delivery. PhD student, Feb 2008 – Feb 2012, awarded.
  • SMITH, A. Smart nano-structures for novel drug delivery systems. PhD student, October 2011 - present