School of Pharmacy and Biomedical Sciences

Staff

Professor Janis Shute

  • Qualifications: BSc, PhD
  • Role Title: Professor of Pharmacology
  • Address: St Michael's Building, White Swan Road, Portsmouth, PO1 2DT
  • Telephone: 023 9284 2152
  • Email: jan.shute@port.ac.uk
  • Department: School of Pharmacy and Biomedical Sciences
  • Faculty: Faculty of Science

Biography

I am head of the Respiratory Immunopharmacology group investigating mechanisms and biomarkers of lung inflammation in patients with cystic fibrosis and novel strategies to improve inhaled drug delivery in these patients. In collaboration with the University of Southampton, the group are jointly developing novel inhibitors of neutrophil elastase, a key mediator of tissue damage in the lung. Other research within the group investigates the role of coagulation factors in bronchial epithelial damage and repair in normal and asthmatic airways; endothelial dysfunction and the links between inflammatory markers and oxidative stress markers.

For more information about my research please visit my lab page

Teaching Responsibilities

  • Level 2; Basic immunology, inflammatory diseases and respiratory physiology
  • MSc; The pathogenesis and treatment of cystic fibrosis and chronic obstructive pulmonary disease
  • Level 3; Pharmacology project supervision
  • M Level; Pharmacy project supervision
  • Postgraduate level; Director of Studies for three PhD students and three MD students

Research

  • Mechanisms of lung inflammation, tissue damage and repair in cystic fibrosis
  • Development of novel mucolytics and new therapeutic applications for heparin
  • Mechanisms of epithelial repair in asthma
  • Mechanisms of inflammatory cell recruitment and its pharmacological manipulation
  • Key research grants obtained in the last 5 years include the Dunhill Medical Trust, the Cystic Fibrosis Trust,  the BBSRC/MoD and Asthma UK
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Research profile

Explore my research profile, publications and activities on the Portsmouth Research Portal

View profile