Summary

I am a Research Fellow in Prof. Anastasia Callaghan’s group. The group is interested in bacterial mechanisms of posttranscriptional gene regulation and how these can be targeted as an antimicrobial strategy, or repurposed as gene expression tools. I bring technical expertise in biochemistry, molecular biology and molecular biodesign to address these aims.

Biography

I graduated from University of Oxford in 2001 with a MChem degree in chemistry, before completing a PhD in Biochemistry and Molecular Biology at University of Miami, Florida under the supervision of Dr Murray Deutscher. My doctoral thesis focused on structure-function studies designed to elucidate the mechanism-of-action of bacterial ribonucleases. In 2008, I accepted a postdoctoral position in Prof. Anastasia Callaghan’s group at University of Portsmouth. During this time, I continued to work on bacterial ribonucleases and also broadened my experience to include interactions involving non-coding regulatory RNAs. In 2012, I moved to Prof. Jason Micklefield’s group at The University of Manchester. During this postdoctoral position, I worked on bacterial riboswitches and their application as novel gene expression tools. Following a career break for maternity leave, I returned to University of Portsmouth in 2016. I re-joined Prof. Anastasia Callaghan’s group as a Visiting Researcher, and then, in 2017, as a Research Fellow.

Research interests

  • The role of ribonucleases in regulating gene expression
  • Mechanisms used by non-coding regulatory RNAs to regulate gene expression
  • Targeting ribonucleases or non-coding RNAs as an antibacterial strategy
  • Developing synthetic gene expression tools based on non-coding regulatory RNAs