I lead the Brain and Behaviour Lab at Portsmouth, which I established in 2015, and act as research lead in the Zebrafish Research Facility. In my group we study the biology of neuropsychiatric, neurodevelopmental, and neurodegenerative disorders, and I have published more than 65 peer reviewed articles, chapters and scholarly reviews in this area, encompassing both laboratory and naturalistic work on compulsive behaviour in a variety of species, including farm, laboratory, zoo and companion animals, and humans. My group use zebrafish as a model species to study these disorders, concentrating on the interaction between molecular (genetic/epigenetic) and environmental (e.g., alcohol, stress) factors, and the associated neural circuits. We then translate these finding to humans, and have an active clinical research programme. Our approach is theoretically guided by the principles of precision medicine, i.e., that understanding the biology of conditions will help develop individualised treatments for patients. Our applied research in humans particularly concentrates on interactions between personality (impulsivity, risk-taking) and external stress on alcohol use and misuse. We currently receive funding from INTERREG Channel (EU); CAPES Foundation (Brazil); Foundation for Liver Research; NIHR Clinical Research Network (CRN); ESRC [via South Coast DTP]; Alzheimer’s Research UK; Petroleum Technology Development Fund (Nigeria).