Mitochondrial abnormalities in the development and progression of human cancers
Novel therapeutic agents targeting mitochondria
Gas6/Axl pathway in cancer
Underlying mechanisms of cancer survival/drug resistance
I am a molecular biologist with a major research interest in genetic abnormalities in human cancers as biomarkers for cancer diagnosis, prognosis and treatment. I gained a PhD in Molecular Oncology and completed my early post-doctoral training at Cancer Research UK and Southampton University, where my research on oxidative DNA damage led to a better clarification of the cytotoxic mechanism of the anti-cancer drug 5-FU. During that period I also established a model which may help to understand the molecular consequences of unbalanced translocations in human cancer. I joined the Neuro-oncology Research Group led by Prof. Geoff Pilkington at Portsmouth University in 2009 and became an HEFCE-funded Senior Research Fellow in 2013, then in 2016 I took on a Senior Lecturer post in the School of Pharmacy & Biomedical Sciences. Currently I am investigating mitochondrial abnormalities in the development and progression of human cancers, novel therapeutic agents targeting mitochondria, the Gas6/Axl pathway in cancer, and underlying mechanisms of cancer survival/drug resistance.
For more information about my research please visit my lab page.