This study is concerned with how exposure to decreased oxygen environments can impact on your blood glucose control, your appetite, inflammation and oxidative stress (a state of imbalance between free radicals, which cause damage to the body, and antioxidants which neutralise the effects of free radicals). Prolonged oxidative stress and inflammation, excessive weight, and poor blood glucose control have been linked to the development of a number of diseases including type 2 diabetes.
We intend to study your responses to breathing three different levels of oxygen, which are equivalent to the level of oxygen that would be available to you at sea level, and at altitudes of ~2,450 m (a moderate altitude similar to that experienced during commercial air flight), and ~4,400 m (a high altitude similar to the permanent altitude research laboratory at Pikes Peak, USA). There is some evidence that altitude and low oxygen environments can improve blood glucose control and decrease appetite. However, the ‘ideal’ low oxygen environment for maximising these beneficial effects is unknown and there is evidence that lower oxygen levels (i.e. higher altitudes) may increase inflammation and oxidative stress. If we can further the understanding of the role of hypoxia on these processes, we may be eventually able to develop ways of using these type of interventions to help individuals with conditions such as type 2 diabetes.
What will participants be doing?
Undertaking an oral glucose tolerance test whilst resting in a semi-reclined position breathing different levels of oxygen. Blood samples and other physiological measures will be taken periodically.
- 1×1 hour screening
- 3×4 hour visits
What will participants receive as a reward for their participation?
Where will participants be going?
Spinnaker Building (Rm 1.07), University of Portsmouth, Cambridge Road, PO1 2EF
Volunteers must be:
- Age: 18-55
- Gender: Male
- Staff/Student/General Public
- Non smoking
- Body Mass Index between 25 and 35 kg.m2
This testing has been reviewed by the Science Faculty ethics committee and been given the following ethics code: SHFEC 2019 - 038B