Design, Synthesis & Biochemical Evaluation of Isoflavone Derivatives with Enhanced Potential for Therapeutic Use
PhDs and postgraduate research
Self-funded PhD students only
School of Pharmacy and Biomedical Sciences
Open all year round
This is a self-funded, 3 year full-time or 6 year part-time PhD studentship. This project is supervised by Dr Karen Ball.
On this PhD, you'll study the design, synthesis and biochemical evaluation of isoflavone derivatives for therapeutic use. The results from biochemical evaluation will feed back into the design process to enhance our understanding of their structure activity relationship.
The work will include:
- The use of biochemical evaluation methods such as chemical synthesis, NMR, IR, GC-MS, HPLC, and cell culture work
- access to a skills development program run by our Graduate School
You'll adapt and develop the existing synthesis process for these isoflavone derivative compounds, diversifying the range of compounds that are created.
You'll confirm the purity of the compounds you synthesise, then evaluate these compounds for their effectiveness at maintaining or improving biological activity. This evaluation will include seeing how the compound effects the growth of oestrogen-dependant breast cancer cells.
You'll also carry out binding assays to assess the interaction between the isoflavone molecules you'll synthesise, and oestrogen receptors.
You may also use other biochemical evaluation methods, such as assessing the metabolic liability and potential toxicity of the compounds you've synthesised, through the study of in vitro metabolism and use of MTT and SRB assays.
The experimental and analytical skills that you develop during this project will prepare you for future work in academia or industry.
Self-funded PhD students only. PhD full-time and part-time courses are eligible for the Government Doctoral Loan.
2020/2021 entry (for October 2020 and February 2021 entries)
Home/EU/CI full-time students: £4,407 p/a
Home/EU/CI part-time students: £2,204 p/a
International full-time students: £16,400 p/a
International part-time students: £8,200 p/a
PhD by Publication
External candidates £4,407 p/a
Members of staff £1,680 p/a*
2021/2022 entry (for October 2021 and February 2022 entries)
PhD and MPhil
Home/EU/CI full-time students: £4,407 p/a*
Home/EU/CI part-time students: £2,204 p/a*
International full-time students: £17,600 p/a
International part-time students: £8,800 p/a
All fees are subject to annual increase.
PhD by Publication
External Candidates £4,407 p/a*
Members of Staff £1,720 p/a*
If you are an EU student starting a programme in 2021/22 please visit this page.
*This is the 2020/21 UK Research and Innovation (UKRI) maximum studentship fee; this fee will increase to the 2021/22 UKRI maximum studentship fee when UKRI announces this rate in Spring 2021.
Some PhD projects may include additional fees – known as bench fees – for equipment and other consumables, and these will be added to your standard tuition fee. Speak to the supervisory team during your interview about any additional fees you may have to pay. Please note, bench fees are not eligible for discounts and are non-refundable.
- A good honours degree or equivalent, or a master’s degree in a medicinal chemistry or biochemistry field.
- Exceptionally, equivalent professional experience and/or qualifications will be considered. All applicants are subject to interview.
- English language proficiency at a minimum of IELTS band 6.5 with no component score below 6.0.
Make an enquiry
For administrative and admissions enquiries please contact firstname.lastname@example.org
How to Apply
When you are ready to apply, you can use our online application form. Make sure you submit a personal statement, proof of your degrees and grades, details of two referees, proof of your English language proficiency and an up-to-date CV.
You can also visit our How to Apply pages to get a better understanding of how the PhD application process works.
Interview date: TBC