Design, Synthesis & Biochemical Evaluation of Isoflavone Derivatives with Enhanced Potential for Therapeutic Use
Self-funded PhD students only
School of Pharmacy and Biomedical Sciences
Open all year round
This is a self-funded, 3 year full-time or 6 year part-time PhD studentship, starting in October 2019 or February 2020. This project is supervised by Dr Karen Ball.
On this PhD, you'll study the design, synthesis and biochemical evaluation of isoflavone derivatives for therapeutic use. The results from biochemical evaluation will feed back into the design process to enhance our understanding of their structure activity relationship.
The work will include:
- The use of biochemical evaluation methods such as chemical synthesis, NMR, IR, GC-MS, HPLC, and cell culture work
- access to a skills development program run by our Graduate School
You'll adapt and develop the existing synthesis process for these isoflavone derivative compounds, diversifying the range of compounds that are created.
You'll confirm the purity of the compounds you synthesise, then evaluate these compounds for their effectiveness at maintaining or improving biological activity. This evaluation will include seeing how the compound effects the growth of oestrogen-dependant breast cancer cells.
You'll also carry out binding assays to assess the interaction between the isoflavone molecules you'll synthesise, and oestrogen receptors.
You may also use other biochemical evaluation methods, such as assessing the metabolic liability and potential toxicity of the compounds you've synthesised, through the study of in vitro metabolism and use of MTT and SRB assays.
The experimental and analytical skills that you develop during this project will prepare you for future work in academia or industry.
Self-funded PhD students only. PhD full-time and part-time courses are eligible for the Government Doctoral Loan.
Home/EU/CI full-time students: £4,327 p/a*
Home/EU/CI part-time students: £2,164 p/a*
International full-time students: £15,900 p/a*
International part-time students: £7,950 p/a*
Please note: all students must also pay bench fees of £6,000 p/a.
By Publication Fees 2018/2019
Members of staff: £1,610 p/a*
External candidates: £4,327 p/a*
*All fees are subject to annual increase.
- A good honours degree or equivalent, or a master’s degree in a medicinal chemistry or biochemistry field.
- Exceptionally, equivalent professional experience and/or qualifications will be considered. All applicants are subject to interview.
- English language proficiency at a minimum of IELTS band 6.5 with no component score below 6.0.
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How to Apply
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Interview date: TBC