Funding

Self-funded PhD students only

Project code

BIOL3661017

Faculty

School of Biological Sciences

Start dates

October/February

Closing date

Applications accepted all year round

Applications are invited for a self-funded, 3 year full-time or 6 year part-time PhD studentship, to commence in February 2019 or October 2019. This practice-based PhD involves investigating the spread of antimicrobial resistant bacteria , and is supervised by Joy Watts (joy.watts@port.ac.uk) and Michelle Hale (michelle.hale@port.ac.uk).

Antibiotics are our first line of defence against bacterial infections, and therefore play a critical role in modern clinical care. However, due to natural processes and the widespread use (and misuse) of antibiotics, antimicrobial resistance (AMR) genes are now widespread in both clinical and natural environments.

Transfer of antimicrobial resistance is a global threat to healthcare systems and human longevity and it is therefore critical that we develop a better understanding of how AMR genes proliferate, persist in the environment, and spread - especially into clinically-relevant pathogenic species.

The work will include:

  • use of the latest molecular and analytical techniques to address the problem

Bacteria obtain resistance to antibiotics in a number of ways: a major route is horizontal gene transfer (HGT) via the processes of transformation, conjugation or transduction in the environment, resulting in a change from a resistant to sensitive strain. Rates of HGT are increased in environmental systems with elevated levels of heavy metals, due to the process of co-selection.

Aquatic sediments contain compounds from historic pollution events such as direct sewage release, industrial contaminants and agricultural waste including aquaculture, resulting in a stratified environment with a complex microbial community.

This PhD will focus on the study of re-suspension of AMR genes in the water column. You'll further analyse the pathways and interactions responsible for AMR transfer, and study sediment microcosm systems to assess the HGT rates of AMR genes in aquatic sediments.

Funding

Funding Availability: Self-funded PhD students only

PhD full-time and part-time courses are eligible for the Government Doctoral Loan

2019/2020 entry

Home/EU/CI full-time students: £4,327 p/a*

Home/EU/CI part-time students: £2,164 p/a*
International full-time students: £15,900 p/a*
International part-time students: £7,950 p/a*

*Fees are subject to annual increase

By Publication Fees 2019/2020

Members of staff: £1,610 p/a*
External candidates: £4,327 p/a*

*Fees are subject to annual increase

Consumables and travel will be covered by bench fees (£6,000) yearly. For more information please contact the project supervisor.

Entry Requirements

Entry requirements

  • A minimum of a second-class honours degree or equivalent in a relevant subject or a master’s degree in an appropriate subject.
  • Exceptionally, equivalent professional experience and/or qualifications will be considered. An online portfolio submission may be required as part of the selection process. All applicants are subject to interview.
  • English language proficiency at a minimum of IELTS band 6.5 with no component score below 6.0.

How to Apply

To start your application, or enquire further about the process involved, please contact Joy Watts (joy.watts@port.ac.uk) and Michelle Hale (michelle.hale@port.ac.uk), quoting both the project code BIOL3661017 and the project title.

You can also visit our How to Apply pages to get a better understanding of how the PhD application process works.

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