Dr Francisco Rios

Lecturer

francisco.rios@port.ac.uk

View my research outputs

Summary

  1. Immune and inflammatory mechanisms underlying cardiovascular fibrosis, with a focus on macrophage‑mediated tissue remodelling and organ damage
  2. Role of the ion channel TRPM7 and magnesium (Mg²⁺) signalling in regulating immune cell function and inflammatory responses in cardiovascular disease
  3. Molecular signalling pathways linking inflammation, vascular dysfunction, and fibrosis in cardiometabolic conditions
  4. Immunopharmacological approaches to identify novel therapeutic targets for hypertension, vascular remodelling, and fibrotic disease

Media availability

X(Twitter): @fjorios

Research outputs

2026

Spike 1 protein of SARS-CoV-2 induces endothelial inflammation and vascular dysfunction through interferon ISG15-dependent mechanisms

Rios, F. J., Montezano, A. C., Camargo, L. L., Lopes, R. A., García-Redondo, A. B., Aranday-Cortes, E., Briones, A. M., McLauchlan, J., Touyz, R. M.

4 Jun 2026, In: Cardiovascular Research

Research output: Article

Neuroinflammation and oxidative stress in Parkinson’s disease, Alzheimer’s disease, and COVID-19: microglia–neutrophil interaction

de Araújo, A. B., Azul, F. V. C. S., Carneiro, Y. C., de Sousa, C. N. S., de Vasconcelos, S. M. M., Rios, F. J., Leal, L. K. A. M.

10 Feb 2026, In: ACS Omega. 11, 5, p. 6922–6938

Research output: Article

A standardized approach for the isolation of vascular smooth muscle cells from carotid atherosclerotic plaques

Byun, J. H., Quintanilla, H. P., Engin, I., Aladeeb, R., Ho, J., He, Y., Rios, F. J., Montezano, A. C., Touyz, R. M., Ragoussis, J., Daskalopoulou, S. S.

12 Jan 2026, In: Scientific Reports. 16, 1, 12p., 1302

Research output: Article

2024

Pharmacological modulation of transglutaminase 2 in the unilateral ureteral obstruction mouse model

Prat-Duran, J., Araujo, I. B. B. A. D., Juste, N., Pinilla, E., Rios, F. J., Montezano, A. C., Touyz, R. M., Simonsen, U., Nørregaard, R., Buus, N. H.

5 Dec 2024, In: European Journal of Pharmacology. 984, 12p., 177037

Research output: Article

Mechanisms of vascular inflammation and potential therapeutic targets: a position paper from the ESH Working Group on Small Arteries

Rios, F. J., de Ciuceis, C., Georgiopoulos, G., Lazaridis, A., Nosalski, R., Pavlidis, G., Tual-Chalot, S., Agabiti-Rosei, C., Camargo, L. L., Dąbrowska, E., Quarti-Trevano, F., Hellmann, M., Masi, S., Lopreiato, M., Mavraganis, G., Mengozzi, A., Montezano, A. C., Stavropoulos, K., Winklewski, P. J., Wolf, J., Costantino, S., Doumas, M., Gkaliagkousi, E., Grassi, G., Guzik, T. J., Ikonomidis, I., Narkiewicz, K., Paneni, F., Rizzoni, D., Stamatelopoulos, K., Stellos, K., Taddei, S., Touyz, R. M., Virdis, A.

1 Jun 2024, In: Hypertension. 81, 6, p. 1218-1232

Research output: Article

SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis

Tobias, E. S., Lucas-Herald, A. K., Sagar, D., Montezano, A. C., Rios, F. J., De Lucca Camargo, L., Hamilton, G., Gazdagh, G., Diver, L. A., Williams, N., Herzyk, P., Touyz, R. M., Greenfield, A., McGowan, R., Ahmed, S. F.

1 May 2024, In: Endocrine. 84, 2, p. 345-349, 5p.

Research output: Article

2023

Recent advances in understanding the mechanistic role of transient receptor potential ion channels in patients with hypertension

Rios, F. J., Sarafian, R. D., Camargo, L. L., Montezano, A. C., Touyz, R. M.

5 Dec 2023, In: Canadian Journal of Cardiology. 39, 12, p. 1859-1873

Research output: Article

Exosomes and the cardiovascular system: role in cardiovascular health and disease

Neves, K. B., Rios, F. J., Sevilla-Montero, J., Montezano, A. C., Touyz, R. M.

15 Nov 2023, In: Journal of Physiology. 601, 22, p. 4923-4936, 14p.

Research output: Article

The importance of microvascular inflammation in ageing and age-related diseases: A position paper from the ESH working group on small arteries, section of microvascular inflammation

Mengozzi, A., De Ciuceis, C., Dell'Oro, R., Georgiopoulos, G., Lazaridis, A., Nosalski, R., Pavlidis, G., Tual-Chalot, S., Agabiti-Rosei, C., Anyfanti, P., Camargo, L. L., Dąbrowska, E., Quarti-Trevano, F., Hellmann, M., Masi, S., Mavraganis, G., Montezano, A. C., Rios, F. J., Winklewski, P. J., Wolf, J., Costantino, S., Gkaliagkousi, E., Grassi, G., Guzik, T. J., Ikonomidis, I., Narkiewicz, K., Paneni, F., Rizzoni, D., Stamatelopoulos, K., Stellos, K., Taddei, S., Touyz, R. M., Triantafyllou, A., Virdis, A.

1 Oct 2023, In: Journal of Hypertension. 41, 10, p. 1521-1543, 23p.

Research output: Article

Expanding the Phenotypic Spectrum of Kenny–Caffey Syndrome

Schigt, H., Bald, M., van der Eerden, B. C., Gal, L., Ilenwabor, B. P., Konrad, M., Levine, M. A., Li, D., Mache, C. J., Mackin, S., Perry, C., Rios, F. J., Schlingmann, K. P., Storey, B., Trapp, C. M., Verkerk, A. J., Zillikens, M. C., Touyz, R. M., Hoorn, E. J., Hoenderop, J. G. J., de Baaij, J. H. F.

1 Sep 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 9, p. E754-E768

Research output: Article

View all my research outputs