I am a Senior Postdoctoral Research Associate in the School of Pharmacy and Biomedical Sciences.
My broad research interests include musculoskeletal research and the development of novel biomimetic materials.
Since arriving at Portsmouth in 2017 my main research focus has been to understand the formation of limpet teeth, which have the highest tensile strength of any biologically occurring material.
I have recently been awarded funding to investigate the role of a specific receptor in mediating soft tissue calcification following blunt trauma.
I graduated from the University of Bath in 2005 with a BSc in Applied Biology, which included a professional training placement in the Experimental and Regenerative Neurosciences group at the University of Western Australia. My final year project in the Cell and Developmental Biology Research Group in Bath was on transdifferentiation of pancreatic buds to liver tissue. I then worked as a technician at UCL then as a Senior Technician at the RVC between 2005 and 2006.
In 2007, I began my PhD at the University of Sheffield where I specialised in mechanically stimulated purinergic signalling between osteoblasts (doi.org/10.1016/j.jbiomech.2011.11.036). I remained in Sheffield for two postdoctoral positions. The first was a priming project to validate a new model for investigation of the effects of inducible tumour associated macrophage depletion in a breast cancer (doi.org/10.1371/journal.pone.0188591). The second was to investigate the role of tumour secreted lysyl oxidase in mediating lesion formation in bone, which was published in Nature (doi.org/10.1038/nature14492).
In 2015, I moved to the Bone and Joint Group at the University of Southampton to work on a UK Regenerative Medicines Platform Acellular Hub funded project to test novel in vitro and in vivo molecular delivery systems.
Since February 2017, I have been at the University of Portsmouth on an interdisciplinary research project between the Schools of Engineering, Pharmacy and Biological Science to develop the strongest composite biomaterial in nature.
My research interests include biomineralisation, breast cancer, cell biology, cell signalling, developmental biology and regenerative medicine, drug repurposing, inflammation, musculoskeletal disorders, pharmacovigilance, pre-clinical research, primary and secondary bone cancers, and synthetic biology.
Since 2017 I have been investigating the teeth of the common limpet (Patella vulgata) which are formed from the strongest known biologically occurring material.
From November 2019 onwards I will be investigating the role of a specific receptor in modulating soft tissue calcification following blunt trauma. This work will be funded by a grant recently awarded by the Defence and Security Accelerator (DASA).