My academic and research interests are in the area of research systems and methodology, specifically how research ethics, governance and integrity processes can impact medical and human participant research. I chair research ethics committees for the NHS, Ministry of Defence and Public Health England, and sit on a variety of advisory boards including the Department of Health's Confidentiality Advisory Group (CAG).
I gained a first class BSc in Biomedical Science at the University of Southampton before joining Professor Steve Wood's laboratory for a PhD in Biochemistry. My doctoral project used X-ray crystallography and related Biophysical methods to inform the rational design of potential drug molecules targetting the pentraxin family of proteins. In 2005 I took up a post-doctoral position working for Professor Sir Mark Pepys FRS at the Centre for Amyloidosis and Acute Phase Proteins at UCL Medical School. In 2006 our work on a depleter of C-reactive protein was published on the front cover of Nature. A second project, developing small molecules targeting the serum protein Transthyretin, contributed towards the group being awarded one of the first Wellcome Trust Seeding Drug Discovery Initiative awards in 2007. This work was patented and licensed to GSK in 2009. I joined the University of Portsmouth in April 2012 as a tenure-track Senior Fellow, and in 2014 received a BBSRC project grant to explore immune proteins involved in complement, and specifically protein-DNA interactions.
While carrying out biomedical research I became increasingly interested in research systems and methodologies. Following an additional bachelors degree in Philosophy, and then Master’s degree in Research Ethics, I moved to the School of Health Care Professions in 2017. My research now focuses on evidence based healthcare and specifically how research ethics, integrity and governance processes can be refined so as to add value to research.
- Research Ethics, Integrity and Governance
- Ethics committee review: quality and consistency
- Outcome reporting bias
- Research Waste
- Research Culture
- Clinical Research Design
- Human Challenge Trials