Dr David Rusling
Summary
**Accepting self-funded PhD students**
Dr David Rusling is a Senior Lecturer in Pharmacology within the School of Pharmacy and Biomedical Sciences at the University of Portsmouth. His research focuses on the self-assembly and recognition of nucleic acid sequences from a biological, therapeutic and nanotech perspective. One of his long-term research projects is seeking to improve the triplex-forming properties of oligonucleotides, a class of DNA-binding agent capable of recognising unique base sequences within the major groove of double-helical DNA. Such molecules have potential to modulate the expression of specific genes, as well as introduce functionality into artificial DNA structures assembled for DNA nanotechnology. David’s recent research has appeared in several prominent journals, including Nucleic Acids Research, ACS Nano, Angewandte Chemie, and Chemical Communications.
Research outputs
2024
Functionalizing DNA origami by triplex-directed site-specific photo-cross-linking
Kalra, S., Donnelly, A., Singh, N., Matthews, D., Del Villar-Guerra, R., Bemmer, V., Dominguez, C., Allcock, N., Cherny, D., Revyakin, A., Rusling, D. A.
15 May 2024, In: Journal of the American Chemical Society. 146, 19, p. 13617–13628, 12p.
Research output: Article
2023
The formation and displacement of ordered DNA triplexes in self-assembled three-dimensional DNA crystals
Zhao, Y., Chandrasekaran, A. R., Rusling, D. A., Woloszyn, K., Hao, Y., Hernandez, C., Vecchioni, S., Ohayon, Y. P., Mao, C., Seeman, N. C., Sha, R.
2 Feb 2023, In: Journal of the American Chemical Society. 145, 6, p. 3599–3605
Research output: Article
Fluorous-directed assembly of DNA origami nanostructures
Zou, J., Stammers, A. C., Taladriz-Sender, A., Withers, J. M., Christie, I., Santana Vega, M., Aekbote, B. L., Peveler, W. J., Rusling, D. A., Burley, G. A., Clark, A. W.
10 Jan 2023, In: ACS Nano. 17, 1, p. 752-759, 8p.
Research output: Article
2021
Triplex-forming properties and enzymatic incorporation of a base-modified nucleotide capable of duplex DNA recognition at neutral pH
Rusling, D. A.
21 Jul 2021, In: Nucleic Acids Research. 49, 13, p. 7256-7266
Research output: Article
2020
DNA structural changes induced by intermolecular triple helix formation
Sayoh, I., Rusling, D. A., Brown, T., Fox, K. R.
28 Jan 2020, In: ACS Omega. 5, 3, p. 1679-1687, 9p.
Research output: Article
Stability of the different arms of a DNA tetrahedron and its interaction with a minor groove ligand
Carter, M. L. J., Rusling, D. A., Gurr, S., Brown, T., Fox, K. R.
1 Jan 2020, In: Biophysical Chemistry. 256, 5p., 106270
Research output: Article