Molecular Mechanisms to Ensure Long-term Healthy Outcomes from Faecal Transplants
PhDs and postgraduate research
Self-funded PhD students only
School of Pharmacy and Biomedical Sciences
Applications accepted all year round
Antibiotics are a cornerstone of modern healthcare - but due to their low financial returns, there's a worrying lack of new antibiotics being developed.
The emergence of antibiotic-resistant bacteria has made the situation worse - and these bacterial strains are now recognised by the World Health Organisation as the greatest threat to mankind.
On this PhD, you'll be part of the solution. You'll explore how altering the composition of the bacteria causing the infection could have positive long-term affects, through faecal transplant.
The work will include:
- Collecting microbial samples from patients suffering from resistant C.Diff infections, prior to and after a faecal transplant
- Using molecular biology, microbiology and high performance chemical analyses to probe the changing nature of GI microbiota and to directly address any long-term deficits
- Helping to prevent the onset of new infections and in doing so, provide a significant saving in patient and healthcare costs
By focusing on the regions of the body which are normally populated with micro-organisms - such as the intestine - it's possible to alter the behaviour and makeup of otherwise dangerous pathogens.
The human intestine harbours more than 1000 different species of bacteria which are essential for health. However, changes to this natural ecosystem alter the balance of healthy and pathogenic bacteria, with potentially devastating consequences -- such as the life-threatening and difficult to treat infection Clostridium difficile (C.diff), which accounts for 2053 deaths in English and Welsh hospitals each year.
One successful treatment for severe infections like C.diff is faecal transplantation from healthy donors. This treatment repopulates the intestinal microbiota of a patient, rebalancing bacterial populations and curing the patient.
The success of this treatment is more than just theoretical: QA hospital has previously carried out two to three faecal transplants a month, saving around £10,000 in treatment costs per patient in addition to curing them.
But despite its success, we don't know what long term effects this treatment has on a patient's complex microbial community, as this is equally important for long-term health.
In collaboration with NHS services, this project will investigate the changes in the intestinal microbiota prior to and after faecal transplant procedures for C. diff, with the objective of determining the long-term changes in Gastro Intestinal (GI) microbiota, and the continued health and wellbeing of the patients.
PhD full-time and part-time courses are eligible for the Government Doctoral Loan.
Please note: bench fees may also apply; please contact the project supervisor for more details.
2020/2021 entry (for October 2020 and February 2021 entries)
Home/EU/CI full-time students: £4,407 p/a
Home/EU/CI part-time students: £2,204 p/a
International full-time students: £16,400 p/a
International part-time students: £8,200 p/a
PhD by Publication
External candidates £4,407 p/a
Members of staff £1,680 p/a*
2021/2022 entry (for October 2021 and February 2022 entries)
PhD and MPhil
Home/EU/CI full-time students: £4,407 p/a*
Home/EU/CI part-time students: £2,204 p/a*
International full-time students: £17,600 p/a
International part-time students: £8,800 p/a
All fees are subject to annual increase.
PhD by Publication
External Candidates £4,407 p/a*
Members of Staff £1,720 p/a*
If you are an EU student starting a programme in 2021/22 please visit this page.
*This is the 2020/21 UK Research and Innovation (UKRI) maximum studentship fee; this fee will increase to the 2021/22 UKRI maximum studentship fee when UKRI announces this rate in Spring 2021.
Some PhD projects may include additional fees – known as bench fees – for equipment and other consumables, and these will be added to your standard tuition fee. Speak to the supervisory team during your interview about any additional fees you may have to pay. Please note, bench fees are not eligible for discounts and are non-refundable.
- A good honours degree or equivalent in a relevant subject or a master’s degree in an appropriate subject.
- Exceptionally, equivalent professional experience and/or qualifications will be considered. All applicants are subject to interview.
- English language proficiency at a minimum of IELTS band 6.5 with no component score below 6.0.
Make an enquiry
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How to Apply
To start your application, or enquire further about the process involved, please contact Informal enquiries are welcome and can be made to Dr Sarah Fouch (firstname.lastname@example.org) and Dr James Brown (email@example.com), quoting both the project code and the project title.
When you are ready to apply, you can use our online application form. Make sure you submit a personal statement, proof of your degrees and grades, details of two referees, proof of your English language proficiency and an up-to-date CV.
You can also visit our How to Apply pages to get a better understanding of how the PhD application process works.